Capsules were broken apart during shipping, there has been no contact from customer support since my initial notification.
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A Neurotrophic Agent Provides a Novel MOA (Mechanism of Action)
The synergistic effect of the ingredients in Pre-DX provides nutritional management of endothelial dysfunction associated with numbness, tingling, and the burning sensation in diabetes patients with neuropathy. It offers a neurotrophic benefit by improving endothelial dysfunction and maintaining blood flow in the vessels that carry important nutrients and oxygen to the peripheral nerves.
Pre-DX is composed of the bioactive forms of essential B vitamins along with other agents that reduce inflammation and oxidative stress and are critical for peripheral nerve health. The L-Methylfolate is ready for immediate usage by the cells and can also improve protection against toxins and diseases.
Science: MOA (Mechanism of Action)

Ingredients:
L-methylfolate (Magnafolate-C) Methylcobalamin & Hydroxocobalamin (vitamins B12) Pyridoxal 5’ phosphate (vitamin B6), N-Acetyl Cysteine (NAC), Alpha Lipoic Acid, Vitamins C, D, E, B1, B2, B3, Pantothenic Acid, Zinc, Selenium, Copper.
Benefits:

The endothelium (the thin layer of cells that line the interior surface of blood vessels) helps maintain blood flow by producing a substance called nitric oxide. Nitric oxide signals the blood vessels to relax corresponding with improved blood flow to peripheral nerves. Studies have shown that endothelial cells produce twice as much nitric oxide in the presence of L-methylfolate.
Maintaining blood flow in the small blood vessels is critical for peripheral nerves to maintain their normal functions, such as peripheral nerve repair and regeneration. This includes production of the myelin sheath, a fatty substance that protects the nerve fibers. Research has demonstrated a significant increase in epidermal nerve fiber density after 6 months of L-methylfolate compared to baseline; further research is ongoing.
Why all the ingredients?
Inadequate nutrition is among the most common causes of a weakened immune system. Experts agree that supporting optimal immune function begins with consuming the essential vitamins, minerals, and other key nutrients.
Vitamin B12 – Methylcobalamin - helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.
Vitamin A - plays a role in the function of various immune cells and the promotion of a healthy antibody response. It is essential in maintaining the integrity of tissues that provide a barrier to unwanted organisms.
Vitamin B6 - Research shows it keeps the immune system healthy by making sure it responds appropriately to external challenges.
Vitamin C - an essential antioxidant and perhaps one of the most well-known nutrients for supporting immune health.
Vitamin D - essential in supporting a healthy immune response. According to the National Institutes of Health, the immune system needs vitamin D to fight off invading bacteria and viruses.
Vitamin E - helps the body maintain normal immune function in people of all ages, including the elderly. It also plays a role in protecting cells from oxidative stress.
L-Methylfolate - 7 times more bioavailable than folic acid and needed to make RNA and DNA, critical to producing new immune cells. Consuming adequate folate can support healthy immune function.
Selenium - is required by several key enzymes that function as antioxidants as well as support and regulate several facets of the immune system.
Zinc - involved in numerous cellular processes and as an antioxidant, plays a role in supporting the immune system.
N-Acetyl Cysteine (NAC) - works by aiding in repairing bodily tissue, promoting white blood cells production, and breaking up thick mucus. NAC’s benefits for respiratory and immune health benefits are so widely known, it has been branded as an “essential medicine” by the World Health Organization.
Alpha Lipoic Acid – Inhibits activation of inflammatory immune system cells, boosts activity of natural and dietary antioxidants such as Coenzyme Q10 and Vitamin C. It also restores and improves normal function to immune system cells and regulates the brain’s immune system response to certain viruses as well as decreasing production of free radicals caused by Escherichia coli and Enterococcus faecalis.
Every ingredient in Pre-DX has a specific purpose in the body that increases the effectiveness and potency of the supplement as well as other protective properties within the cell. The ingredients combined create a synergistic effect to increase cellular protection and Boost your Immune System.
Recommended Dose: 1 Capsule Daily
Pre-DX is a product of Southeast Healthcare Consultants, LLC - DBA Pure Southern Health

Overall rating: 4.5 / 5 from 112 reviews.
Capsules were broken apart during shipping, there has been no contact from customer support since my initial notification.
Eddie N. 1/5 Verified
I cancelled my subscription and still got charged. I want my money back Shalom you're loved 💔
Hahn J. 3/5
Best peptides ever! Love this company. Thank you for being amazing!
Nicole C. 5/5 Verified
Love the PreDX. I honesty think I can tell a difference and I definitely feel more energetic. I will definitely keep it on order!!!
Matthew R. 5/5 Verified
I’ve been taking Pre Dx for over 6 months !! Great product !!
Pat J. 5/5 Verified
It did not work ??please cancel all subscriptions
Cathy E. 1/5 Verified
Good product.
G. David R. 5/5 Verified
Poor packaging, capsule had come apart
Eddie N. 1/5 Verified
Love Pre-DX...I tell everyone about who has neuropathy. Been taking it for years and it helps immensely. The company is good to work with...always on time with my shipment. All around great customer experience and great product!
David L. 5/5 Verified
Timely delivery and good product.
Kenneth B. 5/5 Verified
I have been using for years now. My doctor, Dr. Nancy Netter, is pleased with the results and monitors through blood tests every 6 months.
James H. 5/5 Verified
Of all the various nerve treatment pills, this is the only one that has given me any relief. Doesn't stop all the pain but does let me sleep through the night.
Paul T. 4/5 Verified
Found out I am homozygous for one of the MTHFR variants. Take Pre-Dx every day along my other meds. I think it makes a difference
Margaret P. 5/5 Verified
tfttfi
Rory N. 4/5 Verified
Now that my wife and I are both using this product we need to be able to order more than 180 units in order to get a 90 day supply. Ideally, 270 units would provide 90 days (90 for myself and 180 for my wife). Understanding that there are 60 units per container, is 300 units a reasonable expectation?
Kenneth B. 4/5 Verified
I noticed the pills are smaller and a different color but there wasn't any explanation for the change. The label looks different, and the writing is hard to read to see what has changed
Mildred D. 3/5 Verified
After almost a month, there is no difference.
Marcia C. 2/5 Verified
No Comment
Patricia H. 5/5 Verified
We needed this delivery in advance of our departure for a lengthy trip and it appeared that the delivery would be delayed; however, it came with a day to spare. This is really a USPS advantage but we credited Pure Southern Health for the win.
Kenneth B. 5/5 Verified
So far I’ve been using it for about 6 months and it appears to be helping some. I’m going to use it for a year to see how it works later on.
Arthur G. 4/5 Verified
Great product, my Dr. Recommended
James H. 5/5 Verified
Great product !!!
Pat J. 5/5 Verified
We have used this product for years and have been happy with it.
Kenneth B. 5/5 Verified
Responsive and helpful
Rglenn H. 4/5 Verified
I love how the vitamins are doing.
Sarah A. 5/5 Verified
My pediatrist recommended Pre-Dx and overtime the product helped rebuild the nerve coverings in my feet and I got real relief from the stinging pain of neuropathy! I have recommended it to family and friends and all who have used it have found relief from their neuropathy. Great product and great service…it comes on time through the mail every two months! I am a real customer who was desperate for relief from neuropathy and Pre-Dx did just that! It’ll take a couple of months to do its thing cause it actually fixes the problem instead of masks the problem with prescription drugs. It’s not a quick fix, but it is an actual fix that works over time. I highly recommend to all who struggle with the pain and discomfort of neuropathy!
David L. 5/5 Verified
Great pricing and customer service, shipped very fast in two days and offered free shipping. Been using their peptides for 9 months and high quality outcomes!
Bj F. 5/5 Verified
Great products. Tony is amazing. Consistent, helpful, knowledgeable and accommodating. Great asset to your team! Always available for advice and information.
Julie M. 5/5 Verified
Great product
Jamule C. 5/5 Verified
My doctor prescribed this medication to help me with my bones and I feel like this has helped me tremendously
Debbie B. 5/5 Verified
Great products and great service. Joe goes out of his way to take care of his customers.
Chuck M. 5/5 Verified
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David R. 4/5 Verified
Works well
Jamule C. 5/5 Verified
It is an important treatment.
Rglenn H. 5/5 Verified
I have been using this product for several years without issue; however, my latest order contained several capsules which had opened and spilled inside the bottle causing me to wonder about quality control. At least one of the capsules had a hole in it. I would like to think this issue is a one-off and that it would not happen again.
Kenneth B. 5/5 Verified
5 stars
John W. 5/5 Verified
Great product.
Harold C. 5/5 Verified
My patient gained 10 pounds.
Kimberly S. 1/5 Verified
Wonderful experience. Joe was very helpful and extremely knowledgeable. Definitely will order again.
Chuck M. 5/5 Verified
Very satisfied with the medication and service
Marnie M. 5/5 Verified